May 23-24, 2018
St. Louis, MO

Day One
Wednesday May 23, 2018

Day Two
Thursday May 24, 2018

08.20
Chair’s Opening Remarks


Setting the Foundations – Proving the Animal Microbiome as the Next Disruptive Innovation in Agriculture?


Synopsis

Introduction and Purpose:
Despite high research activity, the animal microbiome field is still in it’s infancy industrially. As researchers understand how the microbiome affects the health and productivity of domestic livestock, there is huge potential to advance new market opportunities gained through microbiome studies. As insights into nutrition can be fundamental to the health & wellbeing in livestock, the purpose of this theme will be to review the current knowledge gained through the microbiome.

08.30
Advancing Microbiome Based Leads Into and Through the Pipeline

  • Jeffrey Watts Research Director - External Innovation , Anti Infectives, Zoetis

Synopsis

  • An improved understanding of the interaction between host and microbiome should provide the springboard for the development of the next generation of innovative animal health products for disease prevention and performance optimization.
  • Entry of microbiome-based products for the regulated space will require the development of lead agents that are capable of delivering on defined product profiles as well as meeting the regulatory requirements of efficacy and safety.
  • At present, the regulatory requirements for a microbiome-based product are not well defined but will sit within the existing regulatory framework.

09.00
The Next Wave of Innovation in Animal Health

Synopsis

  • Why we’re on the cusp of the next wave of innovation in Animal Health
  • How endomicrobial ecology enables faster/better/cheaper products for livestock and companion animals
  • Opportunities and challenges in bringing microbiome-based products to market

09.30
Using Human as an Animal Model – Lessons Learn from Studying Human Microbiome to Benefit Animal Health

  • Sandrine Miller-Montgomery Executive Director, Centre for Microbiome Innovation & Professor of Practice, BioEngineering, UC San Diego

Synopsis

• This presentation will cover a holistic overview of some of the many human microbiome studies. Even if in its early stage, human microbiome science is giving many pointers into which path to investigate for animal microbiome interventions
• Similar to human, livestock, and pets are exposed to a lot of agents that influence their microbiome and this has impacts on their health as well as ours
• Improving Animal Health is a major path to improve human health are we are in a symbiotic relationship

10.00
Morning Refreshments & Speed Networking


Elucidating Mechanisms of Action – Finding Function and Demonstrating Effects of the Gut Microbiota on the Host


Synopsis

Introduction and Purpose:
Despite high research activity, the animal microbiome field is still in it’s infancy industrially. As researchers understand how the microbiome affects the health and productivity of domestic livestock, there is huge potential to advance new market opportunities gained through microbiome studies. As insights into nutrition can be fundamental to the health & wellbeing in livestock, the purpose of this theme will be to review the current knowledge gained through the microbiome.

11.00
Overview of Current Beef Industry, Management Practices, and Opportunities for Microbiome Impacts

  • Steve Bartle Director of Livestock Research, BalinBac Therapeutics

Synopsis

• Review of beef industry segments and production targets
• Review of diet supplementation: nutrients, feed additives, and delivery practices
• Discussion of current practices that impact the gut microbiome, and opportunities

11.30
Manipulation of the Microbiome to Modulate Immunity

Synopsis

• Identifying immunoregulatory commensals that induce immune homeostasis
• Engineering microbiota in the gut to perform a specific function including secreting biomolecules with therapeutic effect
• Exploring the use of microbiota mediated metabolites that shift the microbial composition to a more beneficial population due to the return to a more immune homeostasis

12.00
Role of the Microbiome in Swine Respiratory Disease

Synopsis

  • Polymicrobial respiratory infections are a significant challenge to swine production due to reduced weight gain, morbidities and mortalities, decreased animal welfare, and the need for increased antimicrobial administration.
  • By utilizing the gut-lung axis, microbiome modulation is a potential alternative tool for reducing the effects of polymicrobial respiratory disease on growing swine.
  • Our research has found that several gut microbiome characteristics, such as increased diversity and shifts in microbial composition, are associated with improved outcome following co-infection with two significant respiratory pathogens in swine, porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2).


Screening Methodology – Tools and Technologies to Mine the Microbiome


Synopsis

Introduction and Purpose:
New research in NGS and multi-omic technologies is expected to greatly assist with the accurate mining of the animal microbiome to help identify new industrial applications within nutrition, in-feed additives and pharmaceuticals. The purpose of this theme will be to review how researchers are applying new technologies to accelerate discovery and development.

12.30
Advances in the Human Microbiome and Key Learnings for Animal Health

  • Joseph Petrosino CSO and Director, Alkek Center for Microbiome Research, Diversigen and Baylor College of Medicine

13.00
Lunch & Networking

14.00
Connecting the Who with the Where and the What to Understand the Why

  • Matthew Koci Associate Professor, Immunology, Virology & Host-Pathogen Interactions, NC State

Synopsis

• Understanding host-microbiome communications in food-animals can do as much for our understanding of the microbiome in general as the microbiome can do for food animal health
• Identifying the taxa that correlate with improved performance, immunity, or food safety is an important and critical first step, but the host is more concerned with what the microbes are doing than who is doing it
• Fundamental differences among animal sectors and among production systems within sectors will necessitate differences in how we manipulate the biome


A Renewed Demand for Probiotics and Nutrition – Making Genuine Therapeutic Claims in Animal Health


Synopsis

Introduction and Purpose:
Livestock producers current face many challenges including maintaining human food safety maximizing growth & performance and preventing infectious disease. Pre- and probiotics have emerged as an alternative remedy to antibiotics in-feed that boost immunity and promote growth.
The purpose of this theme will be to review the key industrial applications of administering pre- and probiotics in animals to positively engineer the gut microbiome and promote growth performance.

14.30
Probiotics, the Microbiome, and a Functional Approach to Future Applications to Improve Food Safety, Animal Health, and Productivity

Synopsis

  • The gut of food animals is a complex ecosystem that performs a complex series of function that impact production efficiency as well as animal health and well-being
  • Food security and food safety begin in the gut of food-producing animals, and pathogens are present naturally and are found at very low concentrations and incidences
  • Functionality of the ecological niches within the gut are far more critical than simply listing the members of the population. To be able to improve function of the microbiome from the animal perspective, we must replicate the functionality of the occupants of the varied ecological niches in the gut

15.00
Microbiome-Based Approaches for Probiotic Development in Poultry Production

  • Tim Johnson Associate Professor, University of Minnesota

Synopsis

  • Microbiome profiling can be used to define baseline and identify probiotic candidates
  • Ideal probiotics in poultry are able to colonize, modulate the microbiome, and mitigate disease
  • Interactions between the poultry microbiome and its host exist that correlate with performance

15.30
Probiotics as Alternatives for Antimicrobials and Improving Energy Availability

  • Janet Donaldson Associate Professor and Department Chair, University of Southern Mississippi

Synopsis

  • Probiotics can be used to specifically target pathogens for clearance from a host
  • The way probiotics bind to pathogens vary
  • Probiotics can be used to also increase energy availability for the host

16.30
Afternoon Refreshments & Networking


End of Day Roundtable Discussions


Synopsis

Introduction and Purpose:
With the size and complexity of harnessing the potential of the microbiome in animal health, there still remains a number of fundamental questions to allow scientific researchers to forge a successful path in demonstrating causality for a number of disease indications. The purpose of this theme will be to address questions in an informal setting to build a better understanding of this explosive field of research.

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