Can CBD Help With Depression?

Interest in the potential mental health uses of cannabidiol (CBD) has grown tremendously in recent years, including the use of CBD for depression. CBD is a chemical compound found in the Cannabis sativa plant, also known as marijuana or hemp.

Cannabis contains more than 80 compounds, known as cannabinoids. The main cannabinoid that most people are more familiar with is tetrahydrocannabinol (THC), which is the psychoactive substance that produces the "high" characteristic of marijuana.

Benefits

Despite claims about CBD's purported mental health benefits, it is important to understand that the research on its use is still limited. There have been studies done, but many of these have limitations and further research is needed in order to fully understand CBD's therapeutic potential.

Other studies suggest that CBD may help alleviate symptoms of depression by interacting with serotonin receptors in the brain. Serotonin is a neurotransmitter that plays a role in a range of functions in the body including the regulation of mood. It may help contribute to feelings of happiness and well-being. It is also often implicated in the onset of depression and many types of antidepressant drugs work by increasing serotonin levels in the brain.

One study published in 2018 suggested that cannabidiol does not increase serotonin levels; rather, it appears to work by influencing how the brain responds to serotonin that is already there.

Another study found that CBD had a "clear anti-stress effect," which might play a role in reducing stress levels that contribute to feelings of anxiety and depression.

How It’s Taken

Cannabidiol is available in several different forms, although only those that are ingested are likely to produce any antidepressant-like effects or other mental health benefits. It may be taken orally as an oil, spray, or capsule. CBD may also be added to edible products including beverages, candies, or chewable gummies.

CBD can also be used topically in creams, salves, lotions, and balms, although it is likely to only produce localized effects in this form. E-liquids that are inhaled via vaping are also available, though vaping comes with its own risks.

Possible Side Effects

Most of the available research suggests that CBD is generally well-tolerated and produces few side effects. However, this does not mean that people may not experience any unwanted side effects, which may include:

• Appetite changes
• Mood changes
• Diarrhea
• Anxiety
• Drowsiness
• Nausea
• Dizziness
• Elevated liver enzymes

Safety

According to the World Health Organization, the available evidence suggests that CBD is relatively safe. However, the long-term effects are not entirely clear.

CBD products are not subject to regulation because they are marketed as supplements, which means that you don’t know if you are really getting what is described on the label. Because these products are not regulated, you have no way of knowing for sure what you are getting in terms of purity, safety, and dosage.

• One study found that a whopping 70% of CBD products sold online were mislabeled, with many containing much more THC than the packaging claimed. So while many CBD products are labeled as not containing THC, many do contain significant amounts. This could potentially result in a positive result on a drug test. This is a major concern, particularly if you want to avoid the psychoactive effects of THC.
• Another study found that CBD products may also contain potentially dangerous chemicals and medications, including synthetic cannabinoids and cough medicine. Such contamination could lead to health problems including allergic reactions or drug interactions.

CBD vs. Antidepressants

So how does CBD compare to traditional antidepressants? True comparisons of the effects are not yet possible simply because there is not enough research on CBD’s effects.

However, one animal study suggests that CBD might have some possible benefits by comparison:

• A 2018 study published in Molecular Neurobiology concluded that CBD had promise as a fast-acting antidepressant drug. While traditional antidepressant drugs typically take some time to begin working, research on rodents found that CBD showed rapid and sustained antidepressant-like effects.
• CBD also appears to have relatively few side effects. Antidepressant drugs may sometimes cause things such as appetite changes and sexual side effects.

A Word From Verywell

The bottom line when it comes to CBD's potential as a treatment for depression is that more research is needed. Most of the evidence supporting CBD's antidepressant effects comes from animal studies or small trials, and one of the largest reviews of the research found that the available evidence is not strong enough to recommend CBD as a treatment for depression.

If you are experiencing symptoms of depression, it is important to talk to a doctor or mental health professional. Depression may worsen over time if left untreated, but there are effective treatments available including psychotherapy and medications.

If you are interested in using CBD to alleviate symptoms of depression in conjunction with other treatments, always talk to your doctor first about how to use it and about any possible medication interactions.