Bipolar Disorder Treatment Side Effects of Restoril for Insomnia By Marcia Purse Marcia Purse Marcia Purse is a mental health writer and bipolar disorder advocate who brings strong research skills and personal experiences to her writing. Learn about our editorial process Updated on June 17, 2023 Learn more." tabindex="0" data-inline-tooltip="true"> Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Daniel B. Block, MD Medically reviewed by Daniel B. Block, MD Daniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania. Learn about our Medical Review Board Print Ian Spanier / Cultura / Getty Images Table of Contents View All Table of Contents Side Effects Warnings and Precautions Drug Interactions Dosages Discontinuing Restoril Close What is the most important information I should know about Restoril? You should not take Restoril if:you are pregnant, planning to become pregnant, or are breastfeeding; oryou have a known allergy to temazepam, another ingredient in Restoril, or other benzodiazepines. Restoril (temazepam) is a benzodiazepine used to treat insomnia, a condition where a person has difficulty falling asleep or wakes up frequently throughout the night. It's prescribed only for short-term insomnia therapy, meaning approximately seven to 10 days—it's not a medication a person should take every night. Restoril works by having a depressant effect on the central nervous system (CNS). It does this by increasing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that reduces the ability of nerve cells to send chemical signals in the CNS. As a result, it produces feelings of calm and relaxation. This article discusses Restoril side effects that you might experience and the warnings and precautions you should be aware of before taking this medication. Restoril Side Effects There are a number of side effects that may occur with Restoril. Common side effects include: Drowsiness and tiredness that may persist into the next dayHeadacheNervousnessDizzinessNauseaFeeling hungover-like the next day Due to the persistent drowsiness that may occur with Restoril, it's important that you not drive or engage in any dangerous activity until the tiredness has worn off and you feel fully awake and safe.\ Serious Side Effects In addition, a potentially disturbing and serious effect of taking Restoril is that some people participate in activities when they are sleeping or not fully awake—and they usually do not recall these activities in the morning. Examples include eating, having sex, or even driving. It is essential to notify your doctor if this happens to you or your loved one while taking Restoril. The likelihood of this serious side effect is greater if you drink alcohol or take other medications that make you sleepy. So be sure to avoid alcohol when taking Restoril and tell your doctor all the medications you are taking, including herbals, vitamins, and over-the-counter medications. Other potentially serious side effects that warrant you notifying your doctor right away include: Thinking or behaving differently than normal, like confusion or seeing or hearing things that are not really there (hallucinations) Memory loss Anxiety—some people experience a paradoxical reaction with benzodiazepines, meaning they feel more anxious and agitated instead of feeling more sleepy Trouble breathing, swelling of your tongue, mouth, or lips, and nausea or vomiting—this could signal a severe allergic reaction (seek emergency medical attention in this instance) Warning and Precautions for Restoril It's also important to tell your doctor about any other health problems you have besides insomnia, as it may not be safe for you to take Restoril. For instance, if you have a history of drug addiction, Restoril is likely not a good option for your insomnia, as it can lead to both physical and psychological dependence. Risk of Use With Opioids The FDA requires a black-box warning on this medication for an increased risk of respiratory depression, coma, and death if Restoril is taken with opioids. The concomitant use of both medications should only be used if no alternatives are available, and the dosages and duration should be kept to the minimum. If prescribed both drugs, you should be carefully monitored for signs of respiratory depression and sedation. Restoril Drug Interactions Restoril may interact with certain medications. Some medications that may interact with Restoril include: FluvoxamineKetoconazoleItraconazoleNefazodoneCold and allergy medicinesMuscle relaxersSleeping pillsOther benzodiazepinesOpioid pain medicationsSeizure medicationsAntidepressants Always tell your doctor about any medications, supplements, or substances you currently take to avoid potentially serious drug interactions. Dosages for Restoril Restoril is available in 7.5 mg, 15, mg, 22.5 mg, and 30 mg capsules that are administered orally. The amount that you take each day will depend on the medication's strength. The typical dose for adults is 15 mg taken at bedtime. In some cases, this may be adjusted to as low as 7.5 mg to as high as 30 mg, depending on your doctor's recommendations. Older adults, for example, typically take 7.5 mg per day at bedtime. If you miss a dose of your medication, you should skip the missed dose and take your next dose at it regularly scheduled time. Never take a double dose to make up for a missed dose. Discontinuing Restoril Because Restoril is a benzodiazepine, it can be habit-forming. This medication is a controlled substance categorized as a Schedule IV drug. Taking this medication for extended periods or in higher doses increases the risk of developing dependence. Do not stop taking Restoril suddenly without discussing it with your doctor first. Serious withdrawal symptoms can occur if you stop taking Restoril suddenly, like seizures. To minimize withdrawal symptoms and complications, your doctor may recommend that you taper off Restoril gradually under their guidance. You still may experience some mild withdrawal symptoms like a depressed mood or problems sleeping. 3 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: A systematic review. Front Neurosci. 2020;14:923. doi:10.3389/fnins.2020.00923 U.S. Food and Drug Administration. Restoril (temazepam) capsules USP. Drug Enforcement Administration. Benzodiazepines. By Marcia Purse Marcia Purse is a mental health writer and bipolar disorder advocate who brings strong research skills and personal experiences to her writing. See Our Editorial Process Meet Our Review Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Helpful Report an Error Other Submit