Thorazine Side Effects With Bipolar Disorder

Thorazine (chlorpromazine) is a medication that doctors may sometimes use in inpatient settings to control agitation and mania in people who have bipolar disorder. It is used infrequently and is not FDA-approved as a treatment for bipolar disorder.

Thorazine is used to address symptoms of mania, psychosis, or agitation and not for long-term bipolar disorder management.

Antipsychotic medications such as Thorazine, an older drug, and some of the newer antipsychotics, can be life-saving for people with bipolar disorder. For these people, the benefits of these drugs typically outweigh their risks.

Common Side Effects of Thorazine

Like other medications, Thorazine may have several side effects. Check with your doctor if any of the following side effects continue or are bothersome:

• Constipation
• Decreased sweating
• Dizziness
• Drowsiness
• Dryness of mouth
• Nasal congestion

Less Common Side Effects

Check with your doctor if any of the following side effects continue or are bothersome:

• Changes in menstrual period
• Decreased sexual ability
• Increased sensitivity of skin to sunlight (skin rash, itching, redness or other discoloration of skin, or severe sunburn)
• Swelling or pain in breasts
• Unusual secretion of milk
• Weight gain (unusual)

Phenothiazines can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like tongue movements or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs.

Other serious but rare side effects may also occur. You and your doctor should discuss the good this medicine will do and its risks.

Rare but serious side effects can include:

• Difficulty breathing
• Fast heartbeat
• Fever
• Increased sweating
• Loss of bladder control
• Seizures (which can be an indication of neuroleptic malignant syndrome or a separate side effect in and of itself)
• Severe muscle stiffness
• Unusual tiredness or weakness
  

Notify Your Doctor as Soon as Possible

If you experience any of the following side effects, notify your doctor as soon as possible:

More common: Blurred vision, change in color vision, or difficulty in seeing at night, difficulty in speaking or swallowing, fainting, inability to move eyes, loss of balance control, mask-like face, muscle spasms (especially of face, neck, and back), or restlessness or need to keep moving.

Also notify your doctor as soon as possible if you experience shuffling walk, stiffness of arms or legs, tic-like or twitching movements, trembling and shaking of hands and fingers, twisting movements of body, or weakness of arms and legs.

Less common: Difficulty in urinating; skin rash; sunburn (severe)

Rare: Abdominal or stomach pains, aching muscles and joints, confusion, fever and chills, hot or dry skin, lack of sweating, or muscle weakness.

Thorazine Withdrawal

If you suddenly stop taking Thorazine, you may experience symptoms of withdrawal. Such symptoms may include dizziness, nausea, vomiting, stomach pain, trembling of the fingers and hands, or any of the following symptoms of tardive dyskinesia:

• Lip-smacking or puckering
• Involuntary puffing of cheeks
• Rapid or fine worm-like movements of the tongue
• Uncontrolled chewing movements
• Uncontrolled movements of arms or legs

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.