*All Times Eastern Daylight Time*

8:30 am Registration & Morning Refreshments

8:55 am Chairperson Opening Remarks

9:00 am Panel Discussion: A Strategic View to Harnessing the Animal Microbiome


Topics to be discussed:
• What are the leading candidates for the replacements of antibiotics?
• Where are we likely to see the most progress made?
• What are the challenges we are likely to encounter as the field progresses?

Exploring the Discovery & Application of Probiotics to Improve Gut Health

9:30 am Discussing The Role Probiotics Play in Nutribiosis

  • Leon Marchal Innovation Director , DuPont Nutrition & Bioscience


• Discussing the interaction between nutrition, microbiome and gut and immune function
• Explaining how probiotics can be used to improve gut function

10:00 am Speed Networking & Morning Refreshments

Delving Into How New & Existing Prebiotics & Postbiotics Can Be Harnessed to Improve Animal Health & Nutrition

11:00 am Driving Microbiome Nutritional Technologies Into New Spaces: Implications for Pet Health Apart From the Gut


• We are beginning to understand how nutrition can influence a pet’s microbiome to impact pet health
• The nutrition provided for the gut microbiome affects more than just gut health
• Nutritional technologies which work through the gut microbiome can improve biological markers of both kidney and brain health

11:30 am Decoding the Microbiome’s Contribution to Animal Health & Disease With Metabolomics

  • Brian Keppler Director, Discovery & Translational Sciences, Metabolon Inc.


• Using global untargeted biochemical profiling and targeted metabolite
profiling, Metabolon’s approach can identify microbial-derived
metabolites in the blood the mediate the distal effects on the host ad
can bridge the gap between host/microbiome relationship
• As a sensitive probe of underlying animal physiology, metabolomics
is essential to full elucidating the role of nutrition in wellness and the
development of successful disease prevention strategies
• Metabolomics can empower livestock companies, companion animal
food companies and investigators in the microbiome sciences to achieve
optimal performance in animal husbandry , to optimize vaccine strategies
and to develop innovative dietary components and regimens formulated
for health maintenance and/or disease management

12:00 pm Modulating Microbial Diversity – Opportunities for Health & Wellbeing


• The diversity within the microbiome plays a critical role in gut health and can prevent the growth of pathogenic strains of bacteria such as Salmonella, Campylobacter and Escherichia amongst others
• Increases in microbial diversity are well documented as being associated with an increased resistance to pathogen colonisation
• Nutritional intervention strategies to influence the microfloral diversity can have beneficial impacts on not just pathogen colonisation of the gut but can also positively influence the pathophysiological effects associated with pathogen overburden

12:30 pm Lunch

1:30 pm Understanding Microbiome Therapies, a New Approach to Solving Dysbiosis-Related Challenges as an Alternative to Antibiotic Treatment


•Proteobiotics contain targeted groups of biopeptides that have the ability to disrupt quorum sensing and virulence gene expression of pathogens such as E.coli and Clostridium perfringens
• In-water administration of proteobiotics to broilers challenged on Clostridium perfringens showed a significant reduction in necroticrelated mortality from 24.7% to 13.5%
• In-water administration of proteobiotics to piglets challenged with E. coli during post-weaning period showed 100% reduction in mortality to the same level as the antibiotic treatment

2:00 pm Utilizing Butyrate to Establish a Healthy Gut


• Butyrate positively modulates multiple functions of gut cells including gene expression, cell differentiation, tissue development, immune modulation, oxidative stress reduction and diarrhea control
• Butyrates are increasingly being used to mitigate the disease challenges being faced with the phasing out of antibiotics in livestock operations

Utilizing Technologies To Improve Our Understanding of the Microbiome

2:30 pm Systems Biology Approach to Microbiome Discovery & Probiotic Development


Network analyses for animal microbiome stratification

Metabolic modeling of gut microbiome dynamics

3:00 pm Leveraging Machine Learning & Genomics to Discover Microbial Products


• AgBiome has an expanding collection of 80,000 microbes from 20,000 environments with full genome sequences, as well as numerous assays to evaluate strain performance for product characteristics
• Comparative genomics tools and machine learning (ML) algorithms are at the heart of our technology platform
• I will give an overview of our technology platform and describe a few case studies that exemplify the power of genomics and ML to discover microbial product candidates

Bringing the End User to the Conversation: What Product Innovation Do They Want to See?

3:20 pm Fireside Chat: Bringing the End User to the Conversation: What Product Innovation Do They Want to See?


• How do they look at the microbiome space?
• What innovation are end users expecting hoping to see?

3:50 pm Afternoon Refreshments & Poster Session

Delving Into Early Life Influences on the Microbiota

4:30 pm Effect of Hatchery on Early Colonizing Gastrointestinal Bacteria in Broiler Production

  • Xandra Smith Manager, Microbial Ecology & Genetics , Arm & Hammer


• Microbiota influences the health and production efficiency of poultry, but has found t be highly variable within and between broiler and turkey flocks
• Previous results have shown that microbiota acquired by day-old chicks and poults is mainly influenced by environmental factors at the hatchery
• The objective of this study is to correlate the microbiota from different hatcheries with performance parameters of the broiler flocks

Navigating the Regulatory & Claim Substantiation Landscape of Animal Feed & Therapeutic Products

5:00 pm An Update on the Current Regulatory Landscape


• Provide an insight into the stated Intended use which will drive the regulatory category (Drug, Feed Ingredient, or Biologic) with similar study requirements
• Discuss what claims can be made within each of the regulatory categories

5:30 pm Panel Discussion: All About the Regs


• Developing a better understanding of what pathway to take
• Cost-benefit analysis: Therapeutic or Feed?
• Are the expectations for what you can get out of a microbe or enzyme realistic?

6:00 pm End of Conference Day One