*All Times Eastern Daylight Time*

9:30 am Morning Coffee

Harnessing the Microbiome & the Immune System to Improve Treatment of Disease

10:00 am Connecting the Microbiome to Immune Function Through Metabolomics

  • Matthew Koci Professor, Immunology, Virology & Host-Pathogen , North Carolina State University


• Taxonomic differences may imply more significant biological changes than is realized by the host
• Metabolites and other small molecules likely represent the primary means of communication between commensals and the animal
• The identification of microbiome-derived metabolites that communicate with and augment the function of immune cells will lead to a new “gold rush” in the development of ways to promote host resistance to diseases

10:30 am Exploring Metabolites, Immunity & Disease Resistance


• Diverse groups of gut microbiota influence gut health and disease outcome
• Distinctive biochemical signatures unique to the gut microbial
populations could provide vital link between gut health and novel therapeutics
• Different antibiotic alternatives exert profound effects on metabolites providing novel biochemical signals to maintain intestinal homeostasis

11:00 am Addressing Viral Induced Dysbiosis in the Pulmonary & GI Microbiomes of Production Species


• New drug delivery systems can address challenge posed by viral, bacterial, and protozoal pathogens in the pulmonary and gi systems
• Burdens of disease from viral pathogens like those causing bovine and porcine respiratory disease and african swine fever virus have
huge economic impacts on protein production industries that could be mitigated by veterinary countermeasures of effective new antimicrobials delivered in novel ways
• Microbiome modulation of the virome, bacterial microbiomes, and protozoal microbiomes will lead to healthier herds and flocks and more efficient production systems

11:30 am Morning Refreshments

Exploring Phage Therapy as a Treatment for Infectious Disease

12:00 pm Going Viral Against Bacteria: Implications of Using Phage Therapy In Aquaculture


• Exploring phage therapy against bacterial pathogens
• Delving into phage therapy in Baltic and Mediterranean aquaculture
• Discussing the development of bacterial resistance against bacteriophages

12:30 pm Exploring Phage-Therapy In the Poultry Industry


• Discussing multiple drug resistant infections
• Delving into phages as an antibiotic alternative in broilers
• Extrapolating lessons learnt from phage therapy in Colombia

1:00 pm Lunch

Understanding the Links Between Diet, Nutrition & the Microbiome in Companion Animals

2:00 pm Delving Into How Diet & the Microbiome Interacts to Affect Weight Loss


• Tackling the pet obesity epidemic with microbiome-based approaches
• Microbiome composition in obese versus lean dogs
• Microbiome responses to caloric restriction

2:30 pm Investigating the Effect of Diet on the Gut Microbiome, Metabolomics & Health in Cats


• Characterization of gut microbiome in household cats using metagenomic sequencing
• The effect of diet and probiotics on gut and fecal microbiome in cats

Diving Into the Application of the Microbiome in Aquaculture: What Do We Know & Where Are We Going?

3:00 pm Employing the Genetic Selection Benchmarks for Improving Gut Health & Feed Efficiency in Salmonids Aquaculture

  • Vikas Kumar Assistant Professor, Fish Nutrition & Nutrigenomics , University of Idaho


• Aquaculture provides sustainable production of food fish with high protein/low-saturated fat
• Discussing a vegetarian rainbow trout strain that grows faster that nonselected trout
• Optimizing gut health and feed efficiency in our selected vegetarian trout through genetic selection

3:30 pm Discussing Microbiome Research – The New Frontier for Fish Health?


• The importance of gut microbiome research in the aquaculture industry
• Why should we study the gut bacteria of farmed fish?
• Current antibiotic alternatives used as feed additives in the Norwegian aquaculture industry and their pros and cons

4:00 pm Afternoon Refreshments

Bridging the Research & Commercial Gap

4:30 pm Microbiome Development: Bridging the Gap

  • Scott Carter VP, Microbials Business , Phibro Animal Health


• Moving from idea to marketable product in animal health is full of risks that partners often don’t fully appreciate, resulting in a “valley of death” where many ideas are lost
• To cross this “valley of death” it is vital that all partners understand the challenges and risks well, especially when start-ups are increasingly responsible for innovation
• The Microbiome space represents a vital source of innovation for new animal health interventions, but also brings several unique challenges to overcome while crossing this “valley of death”

5:00 pm Using the Microbiome to Build a Compelling Product Story


• Background of Land O’ Lakes interest in the microbiome
• Opportunities within microbiome space to tell better product story
• Study overview on the impacts of a yeast-based feed additive on the rumen microibome

5:25 pm

Successfully Attracting Investment & Funding to Your Research

5:30 pm Panel Discussion:


Topics to be discussed:
• Fundamentals supporting investor interest in the microbiome
• Key outcomes and milestones needed to obtain investment
• Exploring different stages of investment (Seed, VC, Growth and Buyout)

6:00 pm End of 3rd Microbiome Movement – Animal Health & Nutrition Summit